New Step by Step Map For ceesdekker
New Step by Step Map For ceesdekker
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Utilizing one-molecule optical and AFM imaging and pressure-spectroscopy strategies, we look for to unravel the mechanistic aspects of the composition and dynamics of chromosomes. Our investigation interests involve:
Our team reports bacterial cell division and it is aiming to represent a ‘base up biology’ in synthetic cells that can autonomously divide. Our most important fascination lies in cell division, chromatin structure, and spatial Regulate.
[Laughs] ‘It had been absolutely a terrific chance! At enough time, I used to be properly informed that it could go Completely wrong Which I could turn into a lot less effective, but I just ignored that. Curiosity has usually been my strongest driving force. And fortunately all of it worked out.’
Our work was quickly followed up by Other people, most notably by Phaedon Avouris and colleagues at IBM, who in October 1998 revealed their results on transistors made out of solitary- and multi-walled carbon nanotubes in Utilized Physics Letters.
That is a dream of mine and we set to operate that has a delectable dose of naivety. This is something that will probably yield magnificent ends in the more time expression, but that doesn't issue. You should not only want to work within the queries of tomorrow, but in addition about the inquiries on the day right after tomorrow.’
Our research ranges with the biophysics of DNA to synthetic cells and beyond. Be sure to have a look below for the spectrum of our existing projects.
A lot of connected developments followed, where our team proven distinct transistor variants like one-electron transistors at area temperature and intramolecular nanotube junctions that acted as rectifying diodes, and coupled several transistors into small evidence-of-principle Digital circuits.
Example (one) of bending configurations in 3D simulations of DNA rods on nanopores. A percentage of the membrane is proven in gray, the rim of your pore is highlighted in crimson, in addition to a 3D rendering on the motion on the DNA rod is exhibited.
‘Yes, I recognize individuals ended up surprised at time. At the conclusion of the nineties, when I was in my forties, I used to be Professor of Molecular Electronics and I've to admit that it had turn into a little bit bored, I didn’t find out Substantially any more. The sector went extra into the application facet, how you could integrate nanotubes into Digital circuits.
There was a person problem although — we did not observe any measurable electrical conduction from the single polymer molecules. We concluded that at The only-molecule degree, conducting polymers have been in fact not these terrific conductors, which was rather disappointing. We Therefore broadened our check out to try to discover a lot more promising molecules.
[fourteen] In 2005 Dekker grew to become linked to Netherlands-extensive conversations about Intelligent Style and design, a movement that he has due to the fact clearly distanced himself from. Dekker advocates that science and faith are not in opposition but might be harmonized.
Character Physics thanks the nameless reviewers for their contribution into the peer critique of this do the job.
One example is, we consider the nucleopore sophisticated, a gateway in between the mobile nucleus plus the cytoplasm. This is an extremely complex system and thus tricky to review within a cell, so we use biomimetics. We reconstruct holes cees dekker and afterwards insert specific components of the nucleopore advanced to review transportation by way of it at the single-molecule degree.’
It was an exceptionally fascinating time, for the duration of which I received plenty of guidance from Delft College of Engineering, wherever I had been a professor at the time, and I commenced quite a few collaborations with molecular biologists. That helped me find out quite a bit.’